Discordance among serial biopsies of mosaic embryos

Implantation potential of mosaic embryos.

Chromosomal mosaicism is a relatively common finding in human IVF embryos. However, the association between mosaicism in trophoectoderm and inner mass cells, the mechanisms involved, and its effects on implantation are far from established. We retrospectively reanalyzed array-CGH results from 1,362 trophoectoderm biopsies. We detected chromosomal mosaicism in 183 blastocysts (13.4%). A decrease...

Assessment of bacteriological changes in leprosy, based on serial biopsies.

After a discussion of some of the advantages and disadvantages of the smear technique in estimating the bacteriological changes that occur in patients with leprosy , the author then describes in some detail his method of assessing these changes by the examination of sections of serial biopsy specimens. Although the method, which is fully described, is difficult and cannot be regarded as ideal, ...

Pre-eclampsia: discordance among identical twins.

Breast Cancer Risk and Progressive Histology in Serial Benign Biopsies

Background More than 1 million women per year in the United States with benign breast biopsies are known to be at elevated risk for breast cancer (BC), with risk stratified on histologic categories of epithelial proliferation. Here we assessed women who had serial benign biopsies over time and how changes in the histologic classification affected BC risk. Methods In the Mayo Clinic Benign Bre...

Serial liver biopsies in blood donors with persistent HBs antigenaemia.

Initial liver biopsies from asymptomatic HBs antigen positive blood donors showed a range of histological abnormalities ranging from minor parenchymal lesions to cirrhosis. Twenty of these have now been followed up for periods of up to four years and during that time have had at least two liver biopsies. Throughout the period of study all the donors have remained carriers of HBs Ag, and there w...